Can a disabled person acquire a commercial driver’s license and become an over-the-road truck driver? That usually depends on the nature of the disability. On the surface, the work may look relatively easy since it primarily involves driving. However, the job may require participation in loading and unloading cargo. Entry-level over-the-road jobs typically involve irregular work hours. In addition, driving a semi truck can be physically rigorous as well because of the need for manual shifting and managing a big rig.